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The Week 11 NFL schedule brings key matchups in both conferences, including an AFC showdown between the Buffalo Bills and Kansas City Chiefs on Sunday. Buffalo is riding a five-game winning streak following a 30-20 win over Indianapolis, while Kansas City has won 15 straight games dating back to last season. The Bills are 2.5-point favorites in the Week 11 NFL odds, but they have only covered the spread once in their last five home games against the Chiefs. Should you back either side of that spread with your Week 11 NFL parlay picks?

Another high-level AFC battle will take place in Pittsburgh, where the Steelers will host the Ravens as 3-point underdogs with an over-under of 48.5 in a game that will determine the current AFC North leader. Pittsburgh has won four straight games, but Baltimore is coming off a mini-bye after beating Cincinnati last Thursday and could stay within one of the smallest NFL spreads of the week. Before you make any Week 11 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 11 of the 2024 NFL season on an incredible 17-7 sports betting hot streak on top-rated NFL picks this year. Longer term, it is on a 197-136 roll on top-rated NFL picks that dates back to the 2017 season and a 51-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, the model has scoured the Week 11 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 11 NFL picks at SportsLine.

Top Week 11 NFL picks

After simulating every game 10,000 times, the model is high on the San Francisco 49ers (-6, 48.5) to cover against the Seattle Seahawks. The Seahawks raced out to a 3-0 start this season, but they have lost five of their six games since, including an overtime loss to the Rams in their most recent outing. They also lost to the 49ers by 12 points at home in the first meeting between these rivals this season, and San Francisco's offense has been boosted by the return of star running back Christian McCaffrey. He had 107 yards on 19 touches in his season debut last week, as San Francisco picked up a road win at Tampa Bay

The 49ers have won 10 consecutive games in November and have covered the spread in five of their last six games against the Seahawks. SportsLine's model expects this one-sided rivalry to remain lopsided this week, as San Francisco is covering the spread in well over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 11 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including two teams that win by double-digits and cover with ease. You can only see the model's Week 11 NFL best bets and parlay at SportsLine.

What are the model's top Week 11 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 11 NFL best bets from a model on an 197-136 run on top-rated picks, and find out.

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